John reports on the skirmishes the regiment has engaged around Corinth, TN during the siege. John predicts that a confrontation between the armies here 'will be the most terrible the world has ever witnessed.' He acknowledges the work of attached physicians caring for the regiment's wounded. Letter from John W. Inzer in Ashville, Alabama to John H. Bankhead in Washington, D.C. Tante Johanne: Letters of a Danish Immigrant Family, 1887-1910 Nielsen, John W., J. Christianson, Luther College, Decorah, Iowa on Amazon.com.FREE. shipping on qualifying offers. Tante Johanne: Letters of a Danish Immigrant Family, 1887-1910. Letter from John W. Baker to Julia Ann Baker, 1855 Jan. Baker Follow this and additional works at:This Book is brought to you for free and open access by the Western Americana at Scholarly Commons. It has been accepted for inclusion in Gold Rush.
April 6, 2010
Dr. John P. Holdren
Assistant to the President for Science and Technology
Dear Dr. Holdren:
We, a number of University of California, San Francisco faculty, are writing — see the attached memo — to call your attention to our concerns about the potential serious health risks of the recently adopted whole body back scatter X-ray airport security scanners. This is an urgent situation as these X-ray scanners are rapidly being implemented as a primary screening step for all air travel passengers.
By way of introduction one of us (John Sedat) met you recently when he and his wife Dr. Elizabeth Blacckburn, a 2009 Nobel Laureate, talked with President Obama last ecemer. Dr. Sedat is Professor Emeritus in Biochemistry and Biophyisics at the University of California, San Francisco, with expertise in imagin. He is alo a member of the National Academy of Sciences. The other cosigner incluses Dr. Marc Shuman, an internatioally well known and respected cancer expert and UCSF profesor, as well as Drs. David Agard and Robert Stroud, who are UCSF Professors, X-ray crystallographers, imaging experts and NAS members.
Sincerely yours,
John Sedat, Ph.D
David Agard, Ph.D
Marc Shuman, M.D.
Robert Stroud, Ph.D.
LETTER OF CONCERN
We are writing to call your attention to serious concerns about the potential health risksof the recently adopted whole body backscatter X-ray airport security scanners. This isan urgent situation as these X-ray scanners are rapidly being implemented as a primaryscreening step for all air travel passengers.
Our overriding concern is the extent to which the safety of this scanning device hasbeen adequately demonstrated. This can only be determined by a meeting of animpartial panel of experts that would include medical physicists and radiation biologistsat which all of the available relevant data is reviewed.
An important consideration is that a large fraction of the population will be subject tothe new X-ray scanners and be at potential risk, as discussed below. This raises anumber of ‘red flags’. Can we have an urgent second independent evaluation?
The Red Flags
The physics of these X-rays is very telling: the X-rays are Compton-Scattering off outermolecule bonding electrons and thus inelastic (likely breaking bonds).
Unlike other scanners, these new devices operate at relatively low beam energies(28keV). The majority of their energy is delivered to the skin and the underlyingtissue. Thus, while the dose would be safe if it were distributed throughout the volumeof the entire body, the dose to the skin may be dangerously high.
The X-ray dose from these devices has often been compared in the media to the cosmicray exposure inherent to airplane travel or that of a chest X-ray. However, thiscomparison is very misleading: both the air travel cosmic ray exposure and chest Xrayshave much higher X-ray energies and the health consequences are appropriatelyunderstood in terms of the whole body volume dose. In contrast, these new airportscanners are largely depositing their energy into the skin and immediately adjacenttissue, and since this is such a small fraction of body weight/vol, possibly by one to twoorders of magnitude, the real dose to the skin is now high.
In addition, it appears that real independent safety data do not exist. A search,ultimately finding top FDA radiation physics staff, suggests that the relevant radiationquantity, the Flux [photons per unit area and time (because this is a scanning device)]has not been characterized. Instead an indirect test (Air Kerma) was made thatemphasized the whole body exposure value, and thus it appears that the danger is lowwhen compared to cosmic rays during airplane travel and a chest X-ray dose.
In summary, if the key data (flux-integrated photons per unit values) were available, itwould be straightforward to accurately model the dose being deposited in the skin and adjacent tissues using available computer codes, which would resolve the potentialconcerns over radiation damage.
The Letter That John Wrote
Our colleagues at UCSF, dermatologists and cancer experts, raise specific important concerns:
- A) The large population of older travelers, >65 years of age, is particularly at risk from the mutagenic effects of the X-rays based onthe known biology of melanocyte aging.
- B) A fraction of the female population is especially sensitive to mutagenesis-provoking radiation leading to breast cancer. Notably, because these women, who have defects in DNA rempair mechanisms, are particularly prone to cance,r X-ray mamograms are not performed on them. The dose to breast tissue beneath the skin represents a similar risk.
- C) Blood (white blood cells) perfusing the skin is also at risk.
- D) The population of immunocoompromised individual — HIV and cancer patients (see above) is liekly to be at risk for cancer induction by the high skin dose.
- E) The risk of radiation emmission to childern and adolescents does not appear to have been fully evaulated.
- F) The policy towards pregnant women needs to be defined once the theoretical risks to the fetus are determined.
- G) Because of the proximity of the testicles to the skin, this tissue is at risk for sperm mutagenesis.
- H) Have the effects of the radiation on the cornea and thymus been determined?
Moreover, there are a number of ‘red flags’ related to the hardware itself. Because this device can scan a human in a few seconds, the X-ray beam is very intense. Any glitch in power at any point in the hardware (or more importantly in software) that stops the device could cause an intense radiation dose to a single spot on the skin. Who will oversee problems with overall dose after repair or software problems? The TSA is already complaining about resolution limitations; who will keep the manufacturers and/or TSA from just raising the dose, an easy way to improve signal-to-noise and get higher resolution? Lastly, given the recent incident (on December 25th), how do we know whether the manufacturer or TSA, seeking higher resolution, will scan the groin area more slowly leading to a much higher total dose?
After review of the available data we have already obtained, we suggest that additional critical information be obtained, with the goal to minimize the potential health risks of total body scanning. One can study the relevant X-ray dose effects with modern molecular tools. Once a small team of appropriate experts is assembled, an experimental plan can be designed and implemented with the objective of obtaining information relevant to our concerns expressed above, with attention paid to completing the information gathering and formulating recommendations in a timely fashion. We would like to put our current concerns into perspective. As longstanding UCSF scientists and physicians, we have witnessed critical errors in decisions that have seriously affected the health of thousands of people in the United States. These unfortunate errors were made because of the failure to recognize potential adverse outcomes of decisions made at the federal level. Crises create a sense of urgency that frequently leads to hasty decisions where unintended consequences are not recognized. Examples include the failure of the CDC to recognize the risk of blood transfusions in the early stages of the AIDS epidemic, approval of drugs and devices by the FDA without sufficient review, and improper standards set by the EPA, to name a few.
Similarly, there has not been sufficient review of the intermediate and long-term effects of radiation exposure associated with airport scanners. There is good reason to believ that these scanners will increase the risk of cancer to children and other vulnerable populations. We are unanimous in believing that the potential health consequences need to be rigorously studied before these scanners are adopted. Modifications that reduce radiation exposure need to be explored as soon as possible.
In summary we urge you to empower an impartial panel of experts to reevaluate the potential health issues we have raised before there are irrevocable long-term consequences to the health of our country. These negative effects may on balance far outweigh the potential benefit of increased detection of terrorists.
A Letter From John W. Smith
Original PDF here